Legend says that there was a merchant with rebellious heart who was thirsty and he drank water from a pond in which there were many leaves and flowers of Foxglove plants (Digitalis purpura) floating and on drinking water his rebellious heart inproved.
Old drug used extensively , narrow therauptic index ,still used you need to know every bit of it as it is like uranium which when used properly lights the houses but if used in wrong way blows houses.
Mechanism of action: Increased intracellular calcium by inhibiting Sodium potassium ATPase pump
Onset: IV - 5 minutes
Stays in body for 72 hours in patients with normal kidney function(So be cautious in patients with Renal failure as 60 % excreted unchanged in urine)
Is a positive inotrope and depresses conduction via AV node.
Toxicity: Increased in Hypokalemia, Hypercalcemia, hypomagnesemia, many drugs including Amiodarone, Diuretics
Should I hold am dose on day of surgery: Practice varies but if one is taking for heart failure or resistant arrhythmia it is better to continue on am of surgery with sip of water anesthetizing a patient with controlled heart failure and arrhythmia is easier than one with uncontrolled.
Old drug used extensively , narrow therauptic index ,still used you need to know every bit of it as it is like uranium which when used properly lights the houses but if used in wrong way blows houses.
Mechanism of action: Increased intracellular calcium by inhibiting Sodium potassium ATPase pump
Onset: IV - 5 minutes
Stays in body for 72 hours in patients with normal kidney function(So be cautious in patients with Renal failure as 60 % excreted unchanged in urine)
Is a positive inotrope and depresses conduction via AV node.
Toxicity: Increased in Hypokalemia, Hypercalcemia, hypomagnesemia, many drugs including Amiodarone, Diuretics
Should I hold am dose on day of surgery: Practice varies but if one is taking for heart failure or resistant arrhythmia it is better to continue on am of surgery with sip of water anesthetizing a patient with controlled heart failure and arrhythmia is easier than one with uncontrolled.
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